For example, the uncertainty principle states that you cannot know the momentum and position of a particle at the same time – so you can only know one or the other.
Anyway, stuff is changing all of the time so that, even if you knew everything now, it would be irrelevant the next moment.
No, not by one human alone, and not even by all humans in the world. There’s too much to know, and like Tom said too much of it is changing (though you could know how it was going to change I suppose).
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