Well in all research you are doing experiments that have never been done before to try and find new knowledge. Often these are variations on a theme so not a new method , but a new questions using the same methods- different cells, different conditions for the experiment etc.
However our research group has made new devices for organ transplantation. We made a cooling device to cool organs to protect them in donor bodies before the organ is retrieved. We have also made a machine to restart hearts to test them before transplantation. Although a company has also made one now too.
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