What differences are there between mature and immature B lymphocytes and how do these improve vaccines?

Question: What differences are there between mature and immature B lymphocytes and how do these improve vaccines?
- Keywords:
  lymphocyte,
  vaccine
Asked by LAD to Laura on 9 Mar 2015.
- Laura Garcia Ibanez answered on 9 Mar 2015:
  
  Immature lymphocytes reside in the bone marrow. Mature lymphocytes circulate around the body and the secondary lymphoid organs being ready to encounter with an antigen and mount the antibody response.

Question: What differences are there between mature and immature B lymphocytes and how do these improve vaccines?