It depends what you want to do. Some science roles / health courses need higher grades than others. You would need to check out the entry requirements for what ever you want to do.
If you don’t get good grades, you can sometimes get where you want to be, but it takes longer and you have to do other things to get there e.g bridging courses.
If you want to study say physics, chemistry, biology at university (which is the most common way to become a university-based scientist) then you need to have good grades. Maths is really important. As Gill mentioned, there are other science jobs that have different requirements. Other options are engineering or vocational apprenticeships, where you can become a technician, where you use science/engineering to solve problems: http://technicians.org.uk/
Not necessarily, you need usually B’s or above at GCSE and A Level (it depends on the subject and the uni – some uni’s accept lower). As Stuart said, maths is really important.
Once you get into uni you don’t need to be the top of the class to do well in a career afterwards. Research involves very different skills than just memorising for exams, and everyone is aware of this. Sometimes people with lower grades at uni actually make better researchers (this is the case for me: I never got good grades, but I’m much better at doing the actual research).
I would definitely aim for B’s and above in GGSE’s and A-Levels but yes as Stuart said you can do many science roles without those!! Definitely check out the technicians campaign and apprenticeships with STFC.
Also… I have a friend who got an E in A-Level Biology and she’s now a doctor! So anything can happen if you put your mind to it 🙂
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