Very good question. A key challenge for any drug that works in the brain is over coming the “blood-brain barrier”. This special layer of cells is designed to protect the brain from many chemicals, including a lot of drugs. Drugs that do cross it have very different properties in terms of how basic and water soluble they are.
Making drugs that work on a function of the brain is a challenging process. The drug needs to not only make it through standard digestion but it also needs to cross the blood-brain barrier. This barrier stops chemical from getting into the brain and damaging it. Drugs that are made to cross this barrier have to fulfill certain properties to acheive this.
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