Cramp is a difficult one to predict/avoid/treat, mainly as it has a number of things that cause it. Generally i think you can look at it from two angles, firstly it is likely due to a lack of things getting to the muscle, such as oxygen, nutrients etc which are normally provided by the bloodstream. The second way of looking at it, is there is an increase in negative things that accumulate in muscle as a result of reductions in bloodflow/oxygen delivery.
When we exercise, the body os placed under huge demand from all organs to provide the energy needed. This means that all systems have to work together so that some processes are slowed down in favour off those most important. If the systems providing oxygen/nutrients to muscle cannot cope with the demands of exercise then something has to give, whether it be through muscle damage or cramp. This is basically the bodies way of telling you that you are at the limit.
Training helps as it improves the bodies capacity to provide energy with all the systems becoming more efficient. Nutrition and hydration help as they provide more energy and allow the muscle to contract for longer before fatiguing.
Cramp can also be a result of being dehydrated. If we are dehydrated the build up of waste products that Andrew has mentioned will not be diluted down and flushed out via the kidneys as quickly. When we exercsie we use up a lot of our body water and if we are not replenishing that appropriately we can cramp. This can also be the case when we are sleep. As we sleep for a long time we can dehydrate and the build up of waste products can lead to the sleeping cramp too.
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