how cud a person hv more than 45 chromosomes???wu dn’t it affect him ?

Question: how cud a person hv more than 45 chromosomes???wu dn't it affect him ?
- Keywords:
  biology,
  body,
  chromosome,
  genetics
Asked by shijinkrishnan74 to Becki, Rick on 28 Jun 2013.
- Rebecca Scott answered on 28 Jun 2013:
  
  I did some googling…humans have 23 pairs of chromosomes, so 46 in total. Abnormalities in some of the chromosomes (so missing bits or extra copies) can lead to genetic disorders, such as Down Syndrome or Edward’s Syndrome.

Question: how cud a person hv more than 45 chromosomes???wu dn't it affect him ?