• Question: Yeah, the main problem your research is thst bacteria can all too often find a way around the antibiotics pretty fast and it takes years of tests for the new antibiotics to be released, how do you think this process (of approval) can be shorter, if you had the power to do so, how would you change it?

    Asked by VictorDobos to Daniela ?, ☣ Danna, Jonny, Juan, Lindsay on 15 Jun 2016.
    • Photo: Jonathan Hunter

      Jonathan Hunter answered on 15 Jun 2016:


      I think that the approval process is long of a reason. The FDA (food and drug administration) in the USA have rules on how quickly a drug can be given to the general public.
      The most famous case that is highlighted in this instance is Thalidomide which was an anti morning sickness treatment which caused birth was only found out after it had been put of sale for a length of time. The rules are their to prevent things like this happening with other drugs – like antibiotics.

    • Photo: Daniela Lobo

      Daniela Lobo answered on 15 Jun 2016:


      Hi VictorDobos,

      Jonathan made a good point – the approval process is lengthy, but it is a necessary thing. Since the drug is discovered and manufactured, it takes several steps until it reaches the market, from clinical trials to test its safety to pharmacovigilance post-approval (means looking for the side effects of the drug after already being in the market). This whole process normally takes more than 10 years!
      One interesting thing to think about is the whole process of making an antibiotic. An antibiotic is something that is suppose to be taken for a short number of days, by a certain number of people. It’s a short-term drug in most of the cases (by comparison with a long-term needed drug, like the ones used for chronic diseases, like for example diabetes). That means that the pharmaceutical industry invested all that money and time into making a drug that will bring them little monetary return. For a while, industries were struggling with that and many closed their antibiotic discovery department. That could be one of the reasons why now we have such a small pipeline (set of candidate drugs that a pharmaceutical company has at discovery or development stages) of new antibiotics.

    • Photo: Danna Gifford

      Danna Gifford answered on 16 Jun 2016:


      I think long approval times are a necessary part of drug discovery. There have been drugs in the past that have been given without knowing the full extent of their side effects that have had extremely negative consequences (like thalidimide).

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