I haven’t actually worked on making antibiotics. I work on finding new drugs to treat different diseases but not yet antibiotics. Some antibiotics that we use today have been known for many years are found in natural substances like fungus and mould. There are newer antibiotics which do need chemists to make them though.
I study how bacteria evolve when antibiotics are used to kill them. I sometimes find it surprising and a little scary how easily bacteria can evolve resistance to antibiotics. Some of my work involves trying to find ways to stop bacteria from evolving resistance, by e.g. using two different antibiotics at the same time.
Although my work hasn’t been focused on antibiotics, I have used them as a tool to study bacteria (a type of microbe). But how? When I want to find bacteria that are resistant to an antibiotic I just have to take a big population of bacteria and add the antibiotic to them. All the bacteria will die except those which are resistant to the antibiotic. With antibiotics finding a needle in a haystack becomes a piece of cake!!
Hi Arjan,
well, I don’t directly study antibiotics – I study quick ways of detecting bacteria that could be dangerous to you in, for example, a bioterrorism attack. This requires a high dose of hard work and commitment, a good tablespoon of curiosity and the capacity to accept failures and learn from them.
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