Hi and thank you for the great questions. I’ll start with your last one. We’ve come up with the idea from an observation. We observed that microscopic crystals are sensed by a protein on the cell surface. This protein is maintaining the balance of inflammation and pain in arthritis (disease of the joints). They may show up in the body in case of the disease called gouty arthritis (arthritis with crystals). Crystals help me understand the mechanism of the disease and how to block the pain by working further with them and the protein. So we study this interaction and we try to understand how it all works.